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Topical pain creams and rectal/vaginal suppositories help alleviate localized pain and inflammation while limiting systemic adverse reactions associated with oral use. Topical pain creams and rectal/vaginal suppositories can help patients with temporary pain relief, which can help patients ultimately avoid or decrease the use of oral medications such as opioids. 

Low dose naltrexone (LDN), can promote immune modulation which may reduce inflammatory autoimmune processes and improve mental health. Clinical research has shown that LDN can be used effectively for bodily and mental ailments through its ability to affect the immune system and brain neurochemistry. Low dose naltrexone works by temporarily binding and blocking a mechanism called the MU receptor, which is linked to pain. Blocking this receptor tells the body that it is not producing enough endorphins (natural pain relievers). This prompts the body to naturally release endorphins. LDN has few side effects and can provide many benefits to help manage chronic debilitating conditions.

 

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Ingredients available for compounding in combination. Combinations available based on efficacy and stability. Prices will vary based on combination and strength. Click through for more information:

Products & Pricing

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Cyclobenzaprine 2%, Ibuprofen 10%, Ketoprofen 10%, Piroxicam 2%
KICK Cream

As low as $1.00 per gram 

KICK Cream is a commonly prescribed compounded cream for muscle pain and inflammation. Apply 1/2-1 gram of medication per localized area 2-3 times daily as needed for pain relief. 

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Amitriptyline HCL
Recommended Strength: 0.25-5% cream | 20mg suppository 

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Orally, amitriptyline is used to treat migraines, nerve pain, and depression. Topical amitriptyline is used to treat neuropathic pain and is associated with less systemic side effects when compared to oral use. It also has anti-histamine effects which can help with pruritus (itchy skin), a common side effect of shingles.

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Baclofen
Recommended Strength: 2% cream | 10-20mg suppository

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Baclofen is a muscle relaxant traditionally used for the systemic treatment of spasticity (muscle spasms). Topical application of baclofen can help reduce localized pain while decreasing the side effects when compared to oral baclofen. 

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Camphor
Recommended Strength: 1-10% cream | 7mg suppository 

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Camphor is a mild pain reliever and typically combined with menthol. Camphor and menthol topical is a combination medicine used to relieve minor muscle or joint pain.

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Clonidine
Recommended Strength: 0.01-0.2% cream

Creams: As low as $1.50 per gram

Clonidine is an α2-adrenergic receptor agonist that is used for the treatment of hypertension. Clinical research shows that when used topically, clonidine has potent topical analgesic effects.

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Cyclobenzaprine
Recommended Strength: 0.5-2% cream | 20mg suppository 

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Cyclobenzaprine is a muscle relaxant traditionally taken orally for treatment of muscle spasticity. When taken orally, cyclobenzaprine has many side effects including dizziness and drowsiness. Topical application of cyclobenzaprine helps provide localized reduction in pain and muscle spasticity with minimal side effects. 

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Diazepam
Recommended Strength: 0.5-2% cream | 1-5mg suppository 

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Diazepam is used for muscle spasms and can help reduce vaginal/pelvic tension. Warning: the DEA classifies diazepam as a Schedule IVcontrolled substance due to increased risk of physical dependence. 

 

Warning: the DEA classifies diazepam as a Schedule IV controlled substance due to increased risk of physical dependence.

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Diclofenac Sodium
Recommended Strength: 1-10% cream

Creams: As low as $1.50 per gram

Diclofenac is used topically to reduce localized pain and inflammation.

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Gabapentin
Recommended Strength: 2.5-6% cream | up to 60mg suppository

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Gabapentin is used topically to help with neuropathic pain.

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Ibuprofen
Recommended Strength: 2-20% cream | 400-800mg suppository 

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Ibuprofen is used topically to reduce localized pain and inflammation.

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Lidocaine
Recommended Strengths: 1-10% cream | 20-40mg suppository| 40mg/ml nasal spray 

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Nasal Spray: $44.99 per 30ml 

Lidocaine is used topically to reduce pain. When applied directly to the skin, lidocaine has an onset of approximately 4 minutes. Intranasal lidocaine can be considered a useful option for patients with an acute migraine. It yields a high success rate, a low pain intensity, an infrequent need for rescue medicine, and tolerable adverse events.

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Refer to the following link for more information:

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808552/

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Ketamine HCL
Recommended Strength: 1-10% cream | 7.5mg-30mg suppository

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

When used topically, ketamine is an anaesthetic used in the management of neuropathic pain and complex regional pain syndrome.

 

Warning: the DEA classifies ketamine as a Schedule III controlled substance due to increased risk of physical dependence.

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Menthol
Recommended Strength: 0.5-15% cream

Creams: As low as $1.50 per gram

Menthol causes the skin to feel cool and then warm which helps decrease aches/pains deeper in your muscles and joints. The cooling effect of menthol is also used to temporarily relieve dermatitis and bug bites.

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Piroxicam
Recommended Strength: 0.5-5% cream | 10-20mg suppository 

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Topically, piroxicam is used to decrease localized pain and inflammation. Topical piroxicam has less severe side effects when compared to oral piroxicam. 

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Tetracaine
Recommended Strength: 1-4% cream | 10mg suppository 

Creams: As low as $1.50 per gram

Suppositories: As low as $1.00 each

Tetracaine is a long-acting local anesthetic, used topically to reduce pain and discomfort. It works by blocking nerve signals in your body. Tetracaine may take up to 15 minutes before onset of action. The duration of pain relief is longer than either lidocaine or prilocaine (typically 2-3 hours).

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Low Dose Naltrexone As: Capsules, Lozenges, and Suspensions 

$1.00 per capsule

$44.99 per 30 lozenges 

$44.99 per 60 ml suspension bottle 

Capsule: Common Strengths 1, 1.5, 2, 2.5, 3, 3.5, 4, and 4.5 mg Capsules

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Lozenges: 1,2, and 4 mg lozenges (are scored so they can be cut in fourths)

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Suspension: 2 mg/ml

Liquid Soap

Dexamethasone 4mg/ml Solution for Iontophoresis

$44.99 per 120ml 

Dexamethasone relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis.

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Information contained on this site is provided as an informational aide and for reference use only. The content herein is not intended to be, act as, or replace medical advice or diagnosis for individual health conditions nor is it making evaluations as to the risks or benefits of particular preparations. Please consult a licensed healthcare professional about diagnosis and treatment. Information and statements on this site have not been evaluated by the Food and Drug Administration. All medications and compounds dispensed by Epiphany Compounding require a valid prescription from a medical provider.

 

Photos may not be representative of dispensed product. All medications compounded by Epiphany Compounding are prepared at the direction of a prescription order.

 

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